To play Skip-Bo with 2 players, each player is dealt a stockpile of 30 cards, with the top card turned face up. The remaining cards are placed in a draw pile in the center of the table. Players take turns drawing cards and playing them in sequence from 1 to 12 on one of the four building piles in the center of the table. Players can also use Skip Bo cards as wild cards to start new building piles or to add to existing ones. The game continues until one player empties their stockpile of cards.